CORTEZ, Alex,LI, Yongkai,SINGH, Manmohan,SKIBINSKI, David,WU, Tom Yao-Hsiang,YUE, Kathy,ZHANG, Xiaoyue
申请号：
ES10807754
公开号：
ES2627669T3
申请日:
2010.09.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula (I), or a pharmaceutically acceptable salt thereof: wherein: R1 is alkyl of 1 to 4 carbon atoms, -L1R5, -L1R6, -OL2R5, or -L2R6； L1 is -C (O) - or -O-； L2 is alkylene of 1 to 6 carbon atoms or alkenylene of 2 to 6 carbon atoms, wherein alkylene of 1 to 6 carbon atoms, and alkenylene of 2 to 6 carbon atoms of L2 are optionally substituted with 1 to 4 fluorine groups； each L3 is independently selected from alkylene of 1 to 6 carbon atoms, and - ((CR4R4) pO) q (CH2) p-, wherein the alkylene of 1 to 6 carbon atoms of L3 is optionally substituted with 1 to 4 fluorine groups； L4 is arylene； R2 is alkyl of 1 to 4 carbon atoms； R3 is selected from -OL3R7, O-L3L4L3R7, -OR8, and -OL3L4R5； each R4 is independently selected from H and fluorine； R5 is -P (O) (OH) 2, R6 is -C (O) OH or -CF2P (O) (OH) 2； R7 is -CF2P (O) (OH) 2； R8 is H or alkyl of 1 to 4 carbon atoms； each p is independently selected from 1, 2, 3, 4, 5 and 6, and q is 1, 2, 3 or 4, with the proviso that, when R3 is -OR8, R1 is -L1R5, -L1R6, -L2R5, or where R6 is -CF2P (O) (OH) 2 and R7 is -CF2P (O) (OH) 2.Un compuesto de la fórmula (I), o una sal farmacéuticamente aceptable del mismo: en donde: R1 es alquilo de 1 a 4 átomos de carbono, -L1R5, -L1R6, -OL2R5, o -L2R6； L1 es -C(O)- u -O-； L2 es alquileno de 1 a 6 átomos de carbono o alquenileno de 2 a 6 átomos de carbono, en donde el alquileno de 1 a 6 átomos de carbono, y alquenileno de 2 a 6 átomos de carbono de L2 están opcionalmente sustituidos con 1 a 4 grupos de flúor； cada L3 se selecciona independientemente a partir de alquileno de 1 a 6 átomos de carbono, y - ((CR4R4)pO)q(CH2)p-, en donde el alquileno de 1 a 6 átomos de carbono de L3 está opcionalmente sustituido con 1 a 4 grupos de flúor； L4 es arileno； R2 es alquilo de 1 a 4 átomos de carbono； R3 se selecciona a partir de -OL3R7, O-L3L4L3R7, -OR8, y -OL3L4R5； cada R4 se selecciona independientemente a partir de H y flúor； R5 es -P(O)(OH)2, R6 es -C(O)OH o -CF2P(O)(OH)2； R7 es -CF2
