In one embodiment, a system for electrically stimulating neural tissue of a patient and for determining neurotransmitter release in response to stimulation, the system comprises: pulse generating circuitry for generating electrical pulses at least one electrical lead for conducting electrical pulses generated by the pulse generating circuitry to neural tissue, the at least one electrical lead comprising a plurality of electrodes at least one electrochemical sensor for sensing an extracellular level of one or several neurotransmitters circuitry for sampling a signal from the at least one electrochemical sensor a controller for automatically applying stimulation to neural tissue using a plurality of electrode combinations, the controller generating data related to neurotransmitter release for each of the plurality of electrode combinations and a display for displaying neurotransmitter release for electrode combinations to a clinician.
