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Attenuated live triple G protein recombinant rabies virus vaccine for pre- and post-exposure prophylaxis of rabies
专利权人:
Milosz Faber
发明人:
Milosz Faber,Bernhard Dietzschold,Douglas Craig Hooper
申请号:
US12879335
公开号:
US08282939B2
申请日:
2010.09.10
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention provides a recombinant rabies viruses comprising three copies of a mutated G gene wherein each G gene encodes a rabies virus glycoprotein having the amino acid 194 mutated to a serine and the amino acid 333 is mutated to a glutamic acid. The recombinant rabies virus is nonpathogenic in immunodeficient mammals and can be used in a vaccine to induce an immune response protect mammals from infection by rabies virus as well as clear a pre-existing rabies virus infection from neural tissues.
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