A fluid management system (500) for use in a tissue resection procedure includes a controller (545). An inflow pump (546A) is operated by the controller and configured to provide fluid inflow through a flow path to a site in patient's body. An outflow pump (546B) is operated by the controller and configured to provide fluid outflow through a flow path from the site in patient's body. A motor driven resecting device (515) may be provided for resecting tissue at the site. The controller (545) is configured to actuate an inflow pump (546A) and an outflow pump (546B) in response to various signals and various algorithms are provided to provide malfunction warnings and assure safe operation.