Megastokes amino-triazolyl-BODIPY compounds and applications to live neuron staining and human serum albumin FA1 drug site probing

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专利权人:

National University of Singapore;Agency For Science, Technology and Research

发明人:

Young-Tae Chang,Jun Cheng Er,Cheryl Kit Mun Leong,Seong Wook Yun,Marc Vendrell Escobar,Mui Kee Tang

申请号：

US14648309

公开号：

US09513294B2

申请日:

2013.12.26

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes for human serum albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.

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