Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 μm which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.本發明揭示包含纖維蛋白溶酶原或其生物活性變異體之醫藥組合物。在一實施例中，該組合物包含張力調節劑、增積劑及穩定劑，且具有約3.0至約10.0之pH值。在另一實施例中，該組合物含有低於每100ml 6000個粒子且較佳低於每100ml 2000個粒子之量的等於或大於10μm的呈懸浮形式之粒子。涵蓋此等組合物作為藥劑之用途。亦涵蓋此等醫藥組合物之各種治療用途。
