BUETTELMANN, BERND,JAKOB-ROETNE, ROLAND,KNUST, HENNER,LUCAS, MATTHEW C.,THOMAS, ANDREW
申请号：
CA2757412
公开号：
CA2757412C
申请日:
2010.04.28
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention is concerned withnovel isoxazole derivatives of formula (I) wherein X, R1,R2, R3 and R4 are as described herein, as well as pharmaceuticallyacceptable salts and esters thereof. The activecompounds of the present invention have affinity and selectivityfor GABA A .alpha.5 receptor. Further the present inventionis concerned with the manufacture of the active compoundsof formula (I), pharmaceutical compositions containingthem and their use as medicaments.
