Referring to a Pharmaceutical composition which comprises at least a Neo Antigen Peptide or its pharmaceutically acceptable Salt,A pH modifier and a Carrier wherein at least one Peptide Neo Antigen is determined by PI and Hydro - > 5 > = 8 Pi 6.0, and Hydro - PI < 5 > 8.0, and Hydro - > 5 and < PI > 9, Hydro - 8.PI > 0 or 7 and Hydro - 5.5%. It also relates to a method for preparing Formulation for Vaccine immunogen composition or composition for the Treatment or prevention of Neoplasms.Referido a una composicion farmaceutica caracterizada porque comprende al menos un peptido neo-antigeno o su sal farmaceuticamente aceptable, un modificador de pH y un portador en donde al menos un peptido neo-antigeno es determinado por Pi ≥ 5 e HYDRO ≥ -6.0, Pi ≥ 8 e HYDRO ≥ -8.0, Pi ≤ 5 e HYDRO ≥ -5, Pi ≥ 9 e HYDRO ≤ -8.0, o Pi > 7 e HYDRO ≥ -5.5. Tambien se refiere a un metodo para preparar la formulacion para composicion de vacuna o composicion inmunogena para el tratamiento o prevencion de neoplasias.
