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Pyrimidine derivatives
专利权人:
JANSSEN R&D IRELAND
发明人:
申请号:
ARP130101454
公开号:
AR090880A1
申请日:
2013.04.29
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
The claimed compounds are useful in the treatment of bacterial infections. The claimant also seeks compensation for the ingredients used in the manufacture of the drug for the treatment of bacterial infections, the use of the alleged compound or ingredients and the process of preparation of the alleged compound. 1. Characteristic requirement 1: a formula compound (1) used as medicine, and represents: (1) a formula compound (2);(Ii) -CF(iii) -N (C₁₋₆ alkyl) ₂ (for example -N (CH₃) ₂);o (iv) cicloalquilo C (por ejemplo ciclopropilo)N7515;N.695;N739,N6 696 and n7611;N.695;N739,N6 696 and n7611 can represent - n =;N for 0, 1 or 2 (but preferably 0);X1 and X2 stand for - n-O-C (H) -;When X1 stands for - nQ1 stands for direct link, - C (o) - O-S (o) 8322 -;When X1 stands for - C (H) -,Q1 stands for direct link o-n (r7611) -;R761111 represents c8332121 hydrogen or c833134;Rˣ represents C₁₋₆ alkyl (optionally substituted by one or more substituents that are selected from = O and A¹),Arilo or heterosexual (the latter two types are each replaced by one or more alternatives selected from A2 and A3)Document:R6966,R6966;; 1 and r6966;; independent representative hydrogen, halogen, - CN, - or-83044;-N (R¹¹) (R¹²) or C₁₋₆ alkyl (optionally substituted by one or more halo atoms (eg fluoro));A1,...A3 and a830808 independently represent halides, CN, or1,-S (O) "C" alkyl,C₁₋₆ alkyl (optionally substituted by one or more halo substituents),heterocycloalkyl (optionally substituted by one or more substituents that are selected from C₁₋₃ alkyl and halo),Arilo or heterosexual (the latter two categories can be replaced by one or more alternatives selected by B1 and B2)Document:each R¹ and R¹⁰ independently represent hydrogen, C₁₋₆ alkyl (optionally substituted by one or more halo substituents),aryl or heteroaryl (the latter two groups being optionally substituted by one or more substituents that are selected from halo, C₁₋₃ alkyl and -O-C₁₋₃ alkyl);R¹¹ and R¹² independently represent hydrog
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