BIANUCCI, Anna Maria,BORGHINI, Alice,PIETRA, Daniele
申请号：
IBIB2012/055081
公开号：
WO2013/050902A1
申请日:
2012.09.24
申请国别(地区):
IB
年份:
2013
代理人:
摘要：
A method for making an extract of a plant of the genus Helichrysum in Jojoba oil or wax, in which a step is provided of joining the Helichrysum, preferably the upper parts of the plant, with a Jojoba wax having an acid number higher than 0.3, in particular higher than 0.32, more in particular higher than 0.36. Such method makes it possible to obtain an extract with a high flavonoid content useful for stimulating the keratinocytes of the epidermis, characterised by a content of Chrysin higher than 80 mg/kg of fatty acids having 20 carbon atoms with one unsaturation, in particular higher than 84 mg/kg, more in particular, higher than 104 mg/kg and/or makes it possible to obtain an extract with a low contained of allergens, characterised by a ratio between the amounts of Limonene and β- Selinene lower than 0.4, in particular lower than 0.08, more in particular, lower than 0.06. The step of joining is preferably obtained by a dynamic process, for example by percolation or by centrifugation. A medical or cosmetic composition comprising such an extract for treating or preventing a disease and/or a condition that requires a stimulation of cell proliferation of keratinocytes, among which wounds, burns, skin ulcers, scars, skin aging, stretch marks, wrinkles and others. An insect-repellent composition comprising the extract.Cette invention concerne un procédé de préparation d'un extrait de plante du genre Helichrysum dans l'huile ou la cire de jojoba, comprenant une étape d'association de l'Helichrysum, de préférence, des parties supérieures de la plante, avec une cire de jojoba ayant un indice d'acide supérieur à 0,3, en particulier, supérieur à 0,32, plus particulièrement, supérieur à 0,36. Ce procédé permet d'obtenir un extrait à teneur élevée en flavonoïdes, utile pour stimuler les kératinocytes de l'épiderme, caractérisé par une teneur de chrysine supérieure à 80 mg/kg d'acides gras ayant 20 atomes de carbone portant une saturation, en particulier, supérieure à 84 mg/kg
