Garments comprising functional fabrics and methods of making such garments are disclosed. In certain embodiments, an undergarment is disclosed comprising at least one moisture-absorbent layer of fabric having a first body-contacting side and a second side, and at least one moisture-repellent layer of fabric having a first side disposed adjacent to the second side of the moisture-absorbent layer, and a second side; and a leg cuff comprising a portion of the moisture-repellent layer, a seam and an elongate elastic member.