The present invention generally provides methods for modulating formation ofnew blood vessels. In one embodiment, the methods include administering to amammal an effective amount of granulocyte macrophage-colony stimulating factor(GM-CSF) sufficient to form the new blood vessels. Additionally provided aremethods for preventing or reducing the severity of blood vessel damage in amammal which methods preferably include administering to the mammal aneffective amount of GM-CSF. Provided also as part of this invention arepharmaceutical products and kits for inducing formation of new blood vesselsin the mammal.
