Weenna Bucay-Couto;Hamid Davoudi;Kathleen M Miller;Raymond J. Lareau;Cang Duy Dao;Jianmin LI;Danielle Conley
发明人:
Jianmin LI,Danielle Conley,Weenna Bucay-Couto,Cang Duy Dao,Hamid Davoudi,Raymond J. Lareau,Kathleen M Miller
申请号：
US13404832
公开号：
US20120150096A1
申请日:
2012.02.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer； and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.
