Krull, Harald,Rosenberg, Jorg,Degenhardt, Matthias,Breitenbach, Jorg,Schmidt, Christoph,Kessler, Thomas
申请号：
AU2007224487
公开号：
AU2007224487B2
申请日:
2007.03.12
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
A process for producing a solid dispersion of an active ingredient which comprisesfeeding the active ingredient and a matrix-forming agent to an extruder and forminga uniform extrudate, wherein the extruder comprises at least two rotating shafts(2), each of the shafts (2) carrying a plurality of processing elements disposedaxially one behind the other, the processing elements defining (i) a feedingand conveying section (R； A), (ii) at least one reverse-flight section (D), and(iii) a discharging section (E), wherein the processing elements defining thereverse-flight section (R； D) comprise at least one reverse-flight element(14) which is based on a screw-type element having a conveying direction beingopposite to the general conveying direction of the extruder.
