Muthiah Manoharan,Kallanthottathil G. Rajeev,Marija Prhavc,Ivan Zlatev
申请号：
US13382346
公开号：
US20120157511A1
申请日:
2010.07.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides nucleosides and oligonucleotides comprising a 5′ phosphate mimics of formula (IVc) or (Vc). One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
