The present invention relates to a drug delivery device (100) comprising : - a reservoir (10) for a product, said reservoir having a distally projecting end-piece (20) defining an axial passageway for the transfer of the product, said end-piece having a distal portion (23), - an adaptor (30) having a collar (31 ) engageable around said end-piece, - securing means (13, 24) for locking the axial movement of said collar with respect to said end-piece, wherein said adaptor further comprises a foldable element (36, 34) capable of going from a folded configuration in which said foldable element substantially surrounds said distal portion of said end-piece, and an unfolded configuration, in which said foldable element leaves said distal portion uncovered. The invention also relates to such an adaptor.La présente invention concerne un dispositif dadministration de médicament (100) comportant: un réservoir (10) pour un produit, ledit réservoir comprenant un embout faisant saillie distalement (20) définissant un passage pour le transfert du produit, ledit embout comprenant une partie distale (23) un adaptateur (30) comprenant un col (31) apte à un engagement autour dudit embout des moyens de fixation (13, 24) pour bloquer le déplacement axial dudit col par rapport au dit embout, ledit adaptateur comportant également un élément repliable (36, 34) capable de passer dune configuration repliée dans laquelle ledit élément repliable entoure sensiblement ladite partie distale, et une configuration déployée, dans laquelle ledit élément repliable laisse ladite partie distale exposée. Linvention concerne également un tel adaptateur.