A formulation for topical, dermatologic and/or cosmetic use, in form of hydrophobic gel, oleolite or butter comprising at least one amino acid, at least one hydrophobic vehicle such as oil, silicone or butter, a porous polymer and/or a "spider ester" and/or micro-and nano-particle carriers and vesicular carriers, molecular inclusion systems, thickeners and hydrophobic phase stabilisers, hydrogenating oils, silicone waxes and non-silicone waxes such as bee waxes, silica.