PURPOSE: A complex crude drug extract for treating hyperlipidemia which contains phenyl amide compound is provided to show HMG-CoR inhibition effects and ACAT inhibition effects related to treat and prevent the hyperlipidemia. CONSTITUTION: A complex crude drug extract for treating hyperlipidemia is composed of multiple extract of safflower seed and ginger. The mixing ratio of the safflower seed to ginger is 4:1 in the weight ratio. The Lycii Radicis Cortex extract is additionally added to the extract. The mixing ration of the safflower seed, ginger extract, and the Lycii Radicis Cortex extract is 5:1:1 in the weight ratio. The complex crude drug extract for treating hyperlipidemia is composed of serotonin derivative and tyramine derivative. The mixing ratio of serotonin derivative to the tyramine derivative is 4: 1 in the weight ratio. The serotonin derivative is a mixture of N-(p-coumaroyl) serotonin(CS), N- feruloylserotonin(FS), or a mixture thereof. [Reference numerals] (AA) Ginger+safflower seed； (BB) Ginger 1 : Safflower seed B3； (CC) Ginger 1 : Safflower seed B4； (DD) Ginger 1 : Safflower seed B2； (EE) Ginger 1 : Safflower seed B1； (FF) Ginger 2 : Safflower seed B1； (GG) Ginger 4 : Safflower seed B1； (HH) Ginger 8 : Safflower seed B1； (II) Ginger 1 : Safflower seed A1； (JJ) Ginger 2 : Safflower seed A1； (KK) Ginger 4 : Safflower seed A1； (LL) Ginger 8 : Safflower seed A1본 발명은 고지혈증 치료 및 예방관련한 HMG-CoR 저해효과와 ACAT저해 효과를 나타내는 페닐아마이드 화합물을 유효성분으로 하는 고지혈증 치료용 복합 생약 추출물에 관한 것으로, 상세하게는 천연물인 홍화씨 생강 복합 추출물로 구성된 고지혈증 치료용 조성물에 관한 것이다. 또한 본 발명은 각 추출물로부터 인체에 부작용 또는 독성 등의 우려가 없고 고지혈증 치료 및 예방을 목적으로 하는 페닐아마이드 물질의 제조방법에 관한 것이다.
