Christopher J. Chang,Carolyn R. Bertozzi,Genevieve C. van de Bittner,Elena A. Dubikovskaya
申请号：
US16440348
公开号：
US20190290784A1
申请日:
2019.06.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
