Mccook, John Patrick,Narain, Niven Rajin,Persaud, Indushekhar
申请号：
AU2009233785
公开号：
AU2009233785B2
申请日:
2009.04.09
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present disclosure relates to a method of inducing apoptosis in a cancer cell by delivery of exogenous Coenzyme QlO or its metabolites thereof in a pharmaceutically acceptable carrier to effectuate cell contact of endogenous Coenzyme QlO or its metabolites thereof in addition to but not limited to mevalonic acid and oleic acid to form an intracellular complex. The present disclosure also provides a method of modulating the p53 pathway and Bcl-2 protein family in a manner that restores the apoptotic potential to a cancer cell by delivery of Coenzyme QlO in a pharmaceutically acceptable carrier. The present disclosure further provides a method to specifically normalize the ratio of pro-apoptotic and anti-apoptotic members of the Bcl-2 gene family in a proportion to re-program a cancer cell to undergo apoptosis.
