A probe pen for biological impedance measurement.The probe pen comprises a probe head (10) and a probe handle (20) detachably connected to the probe head (10). The probe head (10) is in contact with the surface of a tissue to be detected, so as to acquire biological impedance information, wherein the probe head (10) comprises a first insulation shell (11), a front end of the first insulation shell (11) is provided with first substrates (12) of a plurality of measuring electrodes (16) which are in regularly geometrical arrangement, and a rear end thereof is provided with an electrically conductive unit (13) and the probe handle (20) comprises a second insulation shell (21) and a circuit board (22) mounted in the second insulation shell (21), and a front end of the circuit board (22) is provided with an electrode connecting unit (23) which can be electrically connected to the electrically conductive unit (13).The probe head (10) and the probe handle (20) can not only realize a reliable connection to one another, but are also easy to disassemble and replace, thereby effectively measuring a biological tissue sample and the probe head (10) and the probe handle (20) are designed separately, thereby reducing usage costs and avoiding cross infection.Linvention concerne un stylo-sonde pour une mesure dimpédance biologique. Le stylo-sonde comprend une tête de sonde (10) et un manche de sonde (20) relié amovible à la tête de sonde (10). La tête de sonde (10) est en contact avec la surface dun tissu à détecter, de façon à acquérir des informations dimpédance biologique, la tête de sonde (10) comprenant une première coque disolation (11), une extrémité avant de la première coque disolation (11) comprend des premiers substrats (12) dune pluralité délectrodes de mesure (16) qui sont en agencement géométrique régulier, et une extrémité arrière de celle-ci comprend une unité électroconductrice (13) et le manche de sonde (20) comprend une seconde coque disolation (21) et une carte de
