The present invention belongs to the chemical medicine, which is specifically involved in the compound or its pharmaceutically acceptable salt, isomer, solvate, crystal, or prodrug as shown by the formula I for the structure containing 9,9,10,10-tetrafluoro-9,10-dihydrophenanthrene and capable of inhibiting the activity of hepatitis C virus, and the medicament composition and the application of compound or composition in the preparation of medicaments. The compound in the present invention has an excellent HCV inhibition efficacy.本發明屬於化學醫藥領域，具體涉及式I所示的一類具有9,9,10,10-四氟-9,10二氫菲結構、能夠抑制C型肝炎病毒活性的化合物或其藥學可接受的鹽、異構體、溶劑合物、結晶或前藥，以及含有這些化合物的藥物組合物和這些化合物或組合物在藥物製備中的應用。本發明的化合物具有良好的HCV抑制效果。
