The invention relates to molecular biology, biotechnology, medicine, veterinary science. A group of inventions is proposed: a fusion protein comprising a ligand to MATN1 protein, and a growth factor of EGF, TGF, FGF, IGF, the construct components are connected via a flexible link, characterized by the amino acid sequence of FIG. 1； such fusion protein further comprising the Fc-fragment of an antibody or a polypeptide binding with FcRn and/or transferrin or a fragment thereof, the construct components connected via a flexible link, characterized by the amino acid sequence of FIG. 1； encoding polynucleotide, codon-optimized for expression in the producer cells or a target organism, a genetic construct for the synthesis of the fusion protein in producer cells, or cells of a target organism, the fusion protein producer, a producer of a genetic construct based on a bacterial cell, a preparation for the regeneration of cartilage containing at least 1 fusion protein or genetic construct as the active agent, in an effective amount, and a physiologically acceptable carrier or buffer solution, for parenteral or, in the case of the preparation based on at least 1 fusion protein containing the transport domain, oral administration, in the latter case the preparation is enclosed in an enteric coating, all variantsCette invention concerne la biologie moléculaire, la biotechnologie, la médecine et la médecine vétérinaire. Le groupe d'inventions proposées comprend : une protéine de fusion comprenant un ligand à la protéine MATN1, et un facteur de croissance de type EGF, TGF, FGF, IGF, les composants de la construction étant reliés par l'intermédiaire d'une liaison souple, caractérisée par la séquence d'acides aminés de Fig. 1 ； ladite protéine de fusion comprenant en outre le fragment Fc d'un anticorps ou un polypeptide se liant à FcRn et/ou à la transferrine ou à un fragment de celle-ci, les composants de la construction étant reliés par l'intermédiaire d'une liaison souple, carac
