Stefanie Dimmeler,Reinier A. Boon,Ariane Fischer,Andreas M. Zeiher
申请号：
US13422932
公开号：
US08871731B2
申请日:
2012.03.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to treating or preventing age-related cardiomyopathy by modulating the expression or activity of a miR-34 family member and/or PNUTS. Methods of treating or preventing age-related cardiomyopathy include administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity. Also provided herein are methods of treating or preventing cardiac fibrosis and myocardial infarction by administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity.
