UNIVERSITY OF NOTRE DAME DUE LAC;THE UNIVERSITY OF CONNECTICUT
发明人:
PRAMOD K. SRIVASTAVA,BRIAN M. BAKER
申请号：
US16560336
公开号：
US20200061168A1
申请日:
2019.09.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described herein are methods of identifying immunologically protective neo-epitopes from the cancer tissue DNA of cancer patients using biophysical principles as well as bioinformatics techniques. The identification of immunologically protective neo-epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a method of using the conformational stability of an epitope in an MHC protein-binding groove to predict immunogenicity of peptides in a putative neo-peptide set from a tumor from a cancer patient. Pharmaceutical compositions and methods of administration are also included.
