A biopsy instrument for removing nodes such as lymph nodes may include one or more of a blade for mechanical cutting of the ducts that connect the node to surrounding tissue and/or an energy emitter for emitting energy to seal the ducts and/or contribute to the gentle removal of the node from its connecting ducts. The biopsy instrument may include a ring clamp assembly made up of two opposing ring structures that may be clamped together such that the desired tissue sample (e.g., a lymph node) is captured within the inside opening of the clamped rings. Connecting ducts may be severed using either a blade or energy emitted from the ring clamps.
