targeted enzyme compounds and uses thereof abstract of the disclosure the present invention is related to a compound that includes (a)? -l-iduronidase (idua), fragment, or analog thereof and (b) a targeting moiety, for example, where compound is a fusion protein including idua and angiopep-2. in certain embodiments, these compounds, owning the presence of the targeting moiety can crossing the blood-brain barrier or accumulating in the lysosome more effectively than the enzyme alone. the invention also features methods for treating mucopolysaccharidosis type i (mps-i) using such compounds. abstract of the subject: "enzyme target compounds and their uses". The present invention relates to a compound comprising (a) alpha-1-iduronidase (idua), its fragment or analog and (b) a targeting moiety, for example, where the compound is a fusion protein including idua and angiopep. -2. In certain embodiments, these compounds, due to the presence of half of bleach can cross the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also provides processes for treating type-1 (mps-i) mucopolysaccharidosis using such compounds.targeted enzyme compounds and uses thereof abstract of the disclosure the present invention is related to a compound that includes (a) ?-l-iduronidase (idua), fragment, or analog thereof and (b) a targeting moiety, for example, where compound is a fusion protein including idua and angiopep-2. in certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. the invention also features methods for treating mucopolysaccharidosis type i (mps-i) using such compounds. tradução do resumo resumo patente de invenção: "compostos enzima alvejados e seus usos". a presente invenção refere-se a um composto que inclui (a) alfa-l-iduronidase (idua), seu fragmento ou análogo e (b) uma metade alvejar,
