CHANG, WONSUK,GUIDRY, ERIN N.,STANTON, MATTHEW G.,ZEWGE, DANIEL
申请号：
CA2900238
公开号：
CA2900238A1
申请日:
2014.02.20
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to RNAi molecules, and compositions thereof, comprising a 2' internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5' end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5' modified nucleotides that comprise, among other potential modifications, a 2' internucleoside linkage. The invention further relates to 5' modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.
