A surgical instrument lubrication system, comprising: a lubrication cartridge (102); a stem (104) defining a primary fluid path; a quarter-turn coupling interface located on each of the lubrication cartridge stem that is operable to sealing mate the lubrication cartridge with the stem, wherein the lubrication cartridge and the stem comprising an initial coupling orientation and a final coupling orientation, and wherein the lubrication cartridge is rotated approximately 90 degrees relative to the stem between the initial coupling orientation and the final coupling orientation; a lubricant reservoir (146) housed in the lubrication cartridge; a metering insert (152) located between the lubricant reservoir and the primary fluid path and operable to meter lubricant flow from the lubricant reservoir to the primary flow path; and an exhaust portion (112) housed in the lubrication cartridge and operable to filter exhaust fluid that passes through the lubrication cartridge.