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Method of storing a vaccine containing an aluminum adjuvant
专利权人:
Sanofi Pasteur
发明人:
Isabelle Chacornac,Nabila Ikhelef-Gribi,Frederic Ronzon,Julien Tirefort,Sandrine Lentsch Graf
申请号:
US14720515
公开号:
US09938055B2
申请日:
2015.05.22
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention relates to a method for loading and storing a vaccine composition, containing the antigen adsorbed on the aluminum adjuvant which (a) comprises (i) loading the composition into a container; and (ii) closing the container with a device in particular acting as a stopper, the surface of the device getting into contact with the composition being coated with a fluoropolymer such as Teflon™ and/or (b) loading the composition into a container wherein the inner surface of which is coated with polymerized silicone. The use of fluoropolymer or polymerized silicone optimizes the adsorbed antigen stability upon storage. In a particular embodiment, the antigen is the hepatitis B surface antigen and the aluminum adjuvant is aluminum oxy hydroxide.
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