Brigitte Benhamou,Gerald Boquet,Jean-Francois Deleuze,Jeffrey M. Karp,Oren Levy,Charles P. Lin,Luke J. Mortensen,Christelle Perrault,Jidong Zhang
申请号：
US15113259
公开号：
US20170216360A1
申请日:
2015.01.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The disclosure relates to methods and compositions for improving homing of cells including mesenchymal stem cells (MSCs). Compositions include compounds described herein as capable of inducing expression by MSCs of cell surface homing ligand molecules such as CD1 la, promoting increased firm adhesion by MSCs in an in vitro shear flow assay, increasing binding to an adhesion molecule such as E-selectin or ICAM-1, and/or demonstrating anti-inflammatory activity upon in vivo systemic administration in cell therapy using human MSCs. Also described are screening methods to identify small molecule compounds for improving a homing function of MSCs.
