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PROTÉINES DE LIAISON À LA PROSTAGLANDINE E2 ET LEURS UTILISATIONS
专利权人:
ABBVIE INC.
发明人:
GU, JIJIE,HUTCHINS, CHARLES, W.,ZHU, RONG-RONG,SHEN, JIANWEI,HARRIS, MARIA, C.,BELANGER, EILEEN,MURTAZA, ANWAR,TARCSA, EDIT,STINE, WILLIAM, B.,HSIEH, CHUNG-MING
申请号:
EP09795127
公开号:
EP2310049A4
申请日:
2009.07.08
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention encompasses prostaglandin E 2 (PGE 2 ) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E 2 and neutralize prostaglandin E 2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E 2 and for inhibiting prostaglandin E 2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E 2 activity is detrimental.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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