Provided are methods and compositions for the treatment and/or prevention of Parkinsons disease in humans. Specifically, the compositions comprising: (a) a population of cells comprising at least 3% dopaminergic neurons, wherein the dopaminergic neurons express FOXA2, Beta-tubulin, and tyrosine hydroxylase (TH), (b) a neurotrophic factor, and (c) a pharmaceutically acceptable carrier and methods for the treatment and/or prevention of Parkinsons disease comprising administering or transplanting a composition comprising dopaminergic neurons derived from the patients own cells.
