GUILLEMONT JEROME EMILE GEORGES,PALANDJIAN PATRICE,DE JONGE MARC RENE,KOYMANS LUCIEN MARIA HENRICUS,VINKERS HENDRIK MAARTEN,VAN AKEN KOEN JEANNE ALFONS,LEWI PAULUS JOANNES,JANSSEN PAUL ADRIAAN JAN,HEE
申请号：
PL40238802
公开号：
PL402388A1
申请日:
2002.08.09
申请国别(地区):
PL
年份:
2013
代理人:
摘要：
the invention concerns pyrimidine derivative of the formula (i '), in which m represents 1,2 or 3； r1 is hydrogen or c1 - 4alkil atom； r2 'means a cyjanowa； x1 is - nh - or - o -； r3 is nr13r14； - c (= o) - c (= o nhr13； -) - nr13r14； - c (= o) - r15； - ch = n - nh - c (= o) - r16； c1 - 6alkil basicsof the nr9r10 or r7； c1 - 6alkil compromised by two substituents cyanogen； c1 - 6alkil compromised by a hydroxyl groups.a second substituent is selected from the group containing the group cyjanowa or r7； c1 - 6alkoksyc1 - 6alkil alternatively a by one group cyjanowa； c2 - 6 - alkenyl compromised by one or two iswniki regardless of each selected from the group of a halogen atom containing, nr9r10, - c (= o) - c (= o nr9r10, -) - c1 - c2 - or 6alkil r7； 6alkenyl compromised by a cyjanowa,a second substituent is selected from the group containing the atom of a halogen group cyjanowa, nr9r10, - c (= o) - nr9r10,- c (= o) - c1 - 6alkil or r7； - c (= n - o - r8) - c1 - 4alkil； r7 or - x3 - r7； x3 is - c (= o) - or - x2 - c1 - 4alkanodiyl - means of a halogen atom； r4, c1 - 6 alkyl, c1 - 6alkoksyl, a nitrowa,a aminowa or r7； r7 is monocykliczna or bicykliczna,saturated or flavouring group karbocykliczna； with each of these pierscieniowych deal could possibly be a karbocyklicznych or heterocyclic by one,two or three substituents； substituents r8, r9 and r10 may in the defined importance； its salts as well as authorized for use in pharmacy or stereochemicznej isomeric form.new relationships show the braking properties of hiv (human deficiency virus odpornosci).in order to powyzszym,the invention concerns also apply to manufacture of new relationship for the treatment of hiv infections and pharmaceutical compositions as an active ingredient zawierajacej pyrimidine derivative of wzothe ( " ").Wynalazek dotyczy pochodnej pirymidyny o wzorze (I"'), w którym m oznacza 1, 2 lub 3； R1 oznacza atom wodoru lub C1-4alkil； R2' oznacza grupe cyjanowa； X1 oznacza -NH- lub -O-； R3 oznacza NR1
