The purpose of the present invention is to provide a novel formulation technology whereby high drug availability can be achieved without inhibiting the diffusion of a drug contained in a formulation. Provided are: a drug-containing ultrafine fiber characterized by comprising an ultrafine fiber that contains a drug; a drug-containing ultrafine fiber laminate formed by laminating the same; and a preparation to be applied to the skin using the drug-containing ultrafine fiber laminate.