Andreas BLUM,Dirk GOTTSCHLING,Armin HECKEL,Joerg HEHN,Thorsten LEHMANN-LINTZ,Dieter WIEDENMAYER
申请号：
US14073907
公开号：
US20140135309A1
申请日:
2013.11.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention relates to novel sulfoximine substituted quinazoline derivatives of formula Iwherein Ar, R1 and R2 are as defined herein, and their use as MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) mediated disorders.
