ЭНДРЮС, Арна (AU),ПАНОУСИС, Кон (AU),ЭММЕРИХ, Керстин (AU),УИЛСОН, Майкл (AU),ДАУЭР, Стив (AU),ХАРДИ, Мэттью (AU),ХАРТМАН, Даллас (AU)
申请号：
RU2018128582
公开号：
RU2018128582A
申请日:
2017.01.06
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
The present invention provides a modified polypeptide which binds Factor VIII. The polypeptide comprises truncated von Willebrand Factor (VWF) which comprises a sequence as shown in SEQ ID NO:3 or a fragment thereof or a sequence 90% identical thereto, wherein the truncated VWF comprises at least one modification in comparison to SEQ ID NO: 3 in at least one position selected from the group consisting of SI, S3, LI 8, V42, S43, K149, N248, S279, V320, T325, Q395 and K418.
