The present application provides a negative pressure wound dressing, including foam and a bio-cellulose film with a three-dimensional reticular structure formed on a surface of the foam, wherein a projected area of the bio-cellulose film on a bonding surface of the foam and the bio-cellulose film is greater than or equal to that of the foam. The presence of the bio-cellulose film between the foam and a wound avoids the foam from sticking to the wound and the growth of new tissue into the foam when performing a negative pressure wound therapy. Also, when replacing the foam, a secondary damage to the wound is reduced, so as to relieve pain that the patient suffers.