Methods and systems related to image segmentation are disclosed. In some examples, a computer system obtains segmentation parameters based on a selection of a region of a displayed image. The selection of the region is associated with a select signal generated by an input device. In response to obtaining the segmentation parameters, the computer system processes the image based on the segmentation parameters. The computer system further adjusts the segmentation parameters based on one or more move signals generated by the input device. The move signal is associated with moving of a representation of the input device within the image. The computer system processes the image based on the one or more adjusted segmentation parameters and displays an image of the selected region based on the processing of the image using the adjusted segmentation parameters.