CHAN, Julian M.W.,ENGLER, Amanda C.,HEDRICK, James L.,KE, Xiyu,NG, Victor W.L.,Sardon, HARIZ,TAN, Jeremy P.K.,YANG, Yi Yan
申请号：
EP14868495
公开号：
EP3076955A4
申请日:
2014.12.03
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
