Polypeptides and agents that bind a TNF receptor superfamily protein are disclosed, particularly agents that specifically bind GITR, OX40, or CD40. The polypeptides or agents may include fusion polypeptides, particularly polypeptides comprising GITRL, OX40L, or CD40L and/or bispecific agents. Also disclosed are methods of using the polypeptides or agents for inducing and/or enhancing the immune response, as well as methods for the treatment of diseases such as cancer.本發明揭示結合腫瘤壞死因子(TNF)受體超家族蛋白之多肽和藥劑,尤其是特異結合GITR、OX40或CD40之藥劑。該多肽或藥劑可包括融合多肽,尤其是包含GITRL、OX40L或CD40L之多肽及/或雙特異性藥劑。本發明亦揭示使用該多肽或藥劑以誘導及/或增強免疫反應的方法以及用於治療疾病(諸如癌症)的方法。
