Paulus Wohlfart;Gerhard Zoller;David William Will;Hartmut Strobel
发明人:
Gerhard Zoller,Hartmut Strobel,David William Will,Paulus Wohlfart
申请号：
US12548636
公开号：
US08399476B2
申请日:
2009.08.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to derivatives of imidazo[1,2-a]pyridines of formula I,in which R, R1 to R4 and n have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO) synthase and are valuable pharmacologically active compounds. Specifically, the compounds of formula I upregulate the expression of the enzyme endothelial NO synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention further relates to processes for the preparation of compounds of formula I, to pharmaceutical compositions comprising them, and to the use of compounds of formula I for the stimulation of the expression of endothelial NO synthase or for the treatment of various diseases including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency, for example.
