PROBLEM TO BE SOLVED: To provide a non-human mammal reacting with various antigens in which correlation with an immune allergic disease is suggested such as ticks or cedar pollen, by establishing a production technology of an antigen-specific CD4 positive T cell clone animal.SOLUTION: There are provided a non-human mammal and a descendant thereof obtained by a somatic nuclear transplantation method by using as a nucleus donor, a nucleus of CD4 positive T cell which is specific to room dust, an insect antigen, a pollen antigen, a dietary antigen or the like, and a preparation method of a non-human mammal to be subjected to somatic nuclear transplantation by using the nucleus of CD4 positive T cell as a nucleus donor.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】抗原特異的CD4陽性T細胞クローン動物の作製技術を確立し、ダニやスギ花粉など、免疫アレルギー疾患との関連性が示唆されているさまざまな抗原に反応する非ヒト哺乳動物を提供すること。【解決手段】室内塵、昆虫抗原、花粉抗原、食餌性抗原等に特異的なCD4陽性T細胞の核を核ドナーとして用い、体細胞核移植法によって得られる、非ヒト哺乳動物及びその子孫、ならびに、CD4陽性T細胞の核を核ドナーとして用いて体細胞核移植する、非ヒト哺乳動物の調製方法。【選択図】なし
