TAKEDA PHARMACEUTICAL COMPANY LIMITED;武田药品工业株式会社;武田藥品工業株式會社
发明人:
藤井伸宽,藤井伸寬,大黑裕哉,佐佐木聪,佐佐木聰,近藤滋
申请号：
MOJ001114
公开号：
MOJ001114B
申请日:
2013.06.20
申请国别(地区):
MO
年份:
2014
代理人:
摘要：
This Hair it is bright provide with Gifted Iso Smo inhibitory activity He More low toxicity compound, as Drug produce product foot Enough Ling Ren Full meaning. The bright compound for providing following formula and indicating of this Hair, Qi Which of Huo, Shi Zhong Ring A Wei Ren Election have 5- to the 7- Yuan Ring of substituent group, and wherein substituent group Ren Election Bi Ci Key closes Xing Cheng Ring； X is O, S or NR1 (R1 is that Hydrogen atom Huo Ren Election has substituent group Hydrocarbon yl)； R2 Wei Ren Election has the carbamoyl of substituent group； And R3 Wei Ren Election has substituent group Hydroxyalkyl base.本發明提供具有優異的Smo抑制活性和較低的毒性的化合物，其作爲藥物産品足夠令人滿意。本發明提供下式表示的化合物，或其鹽，式中環A爲任選具有取代基的5-至7-元環，其中取代基任選彼此鍵合形成環；X爲O、S或NR1(R1爲氫原子或任選具有取代基的烴基)；R2爲任選具有取代基的氨基甲酰基；且R3爲任選具有取代基的羥基。
