A set of instruments is for implantation of an acetabular prosthesis. The set of instruments may include a tool configured to operate in an acetabular cavity of a patient, a first emitter associated with the tool and configured to emit a control signal to be aligned with a reference signal for identifying a correct orientation of the tool relative to the acetabular cavity, and an acetabular reference guide to be fixed to a bone site of the patient separate from the acetabular cavity. The set of instruments may include a second emitter associated with the acetabular reference guide and configured to emit the reference signal.