Long, Li,Luqman, Mohammad,Yabannavar, Asha,Zaror, Isabel,Chen, Bao-Lu,Lu, Xiaogfeng,Lee, Sang Hoon,Hurst, Deborah
申请号：
AU2011201529
公开号：
AU2011201529B2
申请日:
2011.04.05
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011201529B220121101.pdf#####ABSTRACT Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering 5 a therapeutically effective amount of an antagonist anti-CD40 antibody or antigenbinding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen10 binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
