WEST JAMES WILLIAM,SAGERT JASON GARY,BESSETTE PAUL H.,LOWMAN HENRY BERNARD,STAGLIANO NANCY E.,VASILJEVA OLGA,MENENDEZ ELIZABETH EDNA MARY
申请号：
IN2635MUN2014
公开号：
IN2635MUN2014A
申请日:
2014.12.26
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
This invention relates generally to the generation of antibodies monoclonal antibodies including fully human monoclonal antibodies that recognize Jagged 1 and/or Jagged 2 to antibodies . monoclonal antibodies including fully human antibodies that recognize Jagged 1 and/or Jagged 2 and nucleic acid molecules that encode antibodies nucleic acid molecules that encode monoclonal antibodies including fully human cross reactive antibodies that recognize both Jagged 1 and Jagged 2 and to methods of making the anti Jagged antibodies and methods of using the anti Jagged antibodies as therapeutics prophylactics and diagnostics. The invention also relates generally to activatable antibodies that include a masking moiety (MM) a cleavable moiety (CM) and an antibody (AB) that specifically bind to Jagged 1 and Jagged 2 and to methods of making and using these activatable anti Jagged antibodies in a variety of therapeutic diagnostic and prophylactic indications.
