THE PRESENT INVENTIONS RELATES TO SUBSTITUTED PHENYL-3-AZA-BICYCLO[3. 1 .O]HEX-3-YL- METHANONES OF GENERAL FORMULA (I) WHEREIN R1, R2, R3, R4, R5 AND R6 ARE AS HEREIN DESCRIBED OR SALTS THEREOF, PREFERABLY PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF THE INVENTION FURTHER RELATES TO THE MANUFACTURE OF SAID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING A COMPOUND ACCORDING TO GENERAL FORMULA (1), AND THE USE OF SAID COMPOUNDS FOR THE TREATMENT OF VARIOUS CONDITIONS SUCH AS CONDITIONS CONCERNING POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA AS WELL AS COGNITIVE IMPAIRMENTS ASSOCIATED WITH SCHIZOPHRENIA, AIZHEIMER’S DISEASE AND OTHER NEUROLOGICAL AND PSYCHIATRIC DISORDERS. THE COMPOUNDS OF THE INVENTION SHOW GLYCINE TRANSPORTER-1 (GLYT1) INHIBITING PROPERTIES.
