PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
发明人:
LEE, Bok Luel,이복률,PARK, Keun Hwa,박근화,KUROKAWA, Kenji,구로카와겐지
申请号：
KRKR2011/003450
公开号：
WO2011/142573A3
申请日:
2011.05.11
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a vaccine composition containing a WTA (wall teichoic acid) as an active ingredient, and more specifically relates to a vaccine composition for preventing Staphylococcus aureus infections, which contains a WTA purified from Staphylococcus aureus as an active ingredient. The vaccine composition according to the present invention has the advantageous effect of being able to effectively prevent Staphylococcus aureus infections such as acute respiratory infection when used to vaccinate individuals and particularly infants and young children who either have no MBL and/or anti-WTA antibodies, or have a low concentration of the same.La présente invention concerne une composition de vaccin contenant un WTA (acide téchoïque de paroi) en tant que substance active, et plus spécifiquement concerne une composition de vaccin pour prévenir les infections par Staphylococcus aureus, qui contient un WTA purifié à partir de Staphylococcus aureus en tant que substance active. La composition de vaccin selon la présente invention présente leffet avantageux de pouvoir prévenir efficacement des infections par Staphylococcus aureus telles quune infection respiratoire aiguë lorsquelle est utilisée pour vacciner des individus et en particulier des nourrissons et de jeunes enfants qui nont pas de MBL et/ou danticorps anti-WTA, ou ont une faible concentration de ceux-ci.본 발명은 WTA (wall teichoic acid)를 유효성분으로 함유하는 백신 조성물에 관한 것으로, 보다 구체적으로는 포도상구균 (Staphylococcus aureus)으로부터 정제된 WTA를 유효성분으로 함유하는 포도상구균 감염 예방용 백신 조성물에 관한 것이다. 본 발명에 따른 백신 조성물을 MBL 및/또는 항-WTA 항체가 존재하지 않거나, 저 농도로 존재하는 개체, 특히 소아에 접종하는 경우 급성 호흡기 감염과 같은 포도상구균의 감염을 효과적으로 예방할 수 있는 효과가 있다.
