The disclosure relates to systems and methods for acquisition of biosignals with motion sensor-based artifact compensation. One example embodiment is a system for acquisition of biosignals from a subject. The system includes at least one biosensor worn over a first location of a body part of the subject configured for biosignal measurement and providing a measured biosignal. The system also includes a plurality of inertial motion sensors worn over a plurality of locations of the body part of the subject. Each of the inertial motion sensors is configured for providing a motion vector signal. The system further includes a biosignal adaptation unit configured for receiving and adapting the measured biosignal. In addition, the system includes a motion estimation unit. Further, the system includes a digital filter unit. At least one of the plurality of inertial motion sensors is mechanically connected to the at least one biosensor.
